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Results for "

SIRT1 activator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (4) Apoptosis (8) Autophagy (12) Bacterial (5) Biochemical Assay Reagents (1) c-Myc (1) COX (1) Dihydroorotate Dehydrogenase (3) EGFR (1) Endogenous Metabolite (4) ERK (1) Fatty Acid Synthase (FASN) (1) Fungal (4) GABA Receptor (1) Histone Methyltransferase (2) IKK (4) Isotope-Labeled Compounds (2) Keap1-Nrf2 (7) MDM-2/p53 (4) Mitophagy (5) NF-κB (1) p38 MAPK (1) Phosphodiesterase (PDE) (1) PI3K (1) PPAR (1) Reactive Oxygen Species (3) Sirtuin (40) TNF Receptor (1)
By Research Areas:	Cancer (28) Cardiovascular Disease (3) Infection (6) Inflammation/Immunology (11) Metabolic Disease (14) Neurological Disease (9)

By Targets:

Antibiotic (4)

Apoptosis (8)

Autophagy (12)

Bacterial (5)

Biochemical Assay Reagents (1)

c-Myc (1)

COX (1)

Dihydroorotate Dehydrogenase (3)

EGFR (1)

Endogenous Metabolite (4)

ERK (1)

Fatty Acid Synthase (FASN) (1)

Fungal (4)

GABA Receptor (1)

Histone Methyltransferase (2)

IKK (4)

Isotope-Labeled Compounds (2)

Keap1-Nrf2 (7)

MDM-2/p53 (4)

Mitophagy (5)

NF-κB (1)

p38 MAPK (1)

Phosphodiesterase (PDE) (1)

PI3K (1)

PPAR (1)

Reactive Oxygen Species (3)

Sirtuin (40)

TNF Receptor (1)

By Research Areas:

Cancer (28)

Cardiovascular Disease (3)

Infection (6)

Inflammation/Immunology (11)

Metabolic Disease (14)

Neurological Disease (9)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15262

SRT 2104 10+ Cited Publications	Sirtuin	Neurological Disease Metabolic Disease Cancer
SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD ⁺ dependent deacetylase *Sirt1, increases Sirt1* protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntington’s disease .

HY-111317

SIRT1 activator 3	Sirtuin	Metabolic Disease
SIRT1 activator 3 is a potent activator of *Sirt1* and suppresses TNF-α in a dose-dependent manner. SIRT1 activator 3 has the potential for anti-obesity or anti-diabetic researches .

HY-N12386

SIRT1 activator 1	Sirtuin	Cancer
SIRT1 activator 1(compound 3) is a derivative of marine compound xyloallenoide A isolated from the mangrove fungus Xylaria sp.SIRT1 activator 1 shows angiogenic activities in zebrafish. SIRT1 activator 1 protects hEPC against AngII-induced senescence by increasing *SIRT1* expression levels and balancing the AMPK/Akt signaling pathway .

HY-162050

8AQ−Cu−5Iu	Sirtuin	Neurological Disease
8AQ?Cu?5Iu is an activator of *SIRT1. 8AQ?Cu?5Iu exhibits neuroprotective effects by modulating the SIRT1/3-FOXO3a* signaling pathway. 8AQ?Cu?5Iu can used in study attenuating neurodegenerative diseases .

HY-114981

SRTCX1002	Sirtuin	Inflammation/Immunology
SRTCX1002 is a potent activator of *SIRT1* (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC₅₀s of 0.71 and 7.58 µM, respectively .

HY-N10083

Selaginellin	Reactive Oxygen Species Sirtuin	Cancer
Selaginellin is an inhibitor of Reactive Oxygen Species and an activator of *SIRT1. Selaginellin protects endothelial cells against homocysteine-induced senescence by inhibitng reactive oxygen species and upregulating SIRT1* gene expression .

HY-136094

SRT3657

Sirtuin Neurological Disease

SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect .
HY-N10125

Ainsliadimer C

Sirtuin Metabolic Disease

Ainsliadimer C, a potential activator of SIRT1, ameliorates inflammatory responses in adipose tissue.
HY-15869

Inauhzin

2 Publications Verification

INZ
Sirtuin MDM-2/p53 Cancer

Inauhzin is a dual SirT1/IMPDH2 inhibitor, and acts as an activator p53, used in the research of cancer.
HY-124240

SRTCX1003

Sirtuin Inflammation/Immunology

SRTCX1003 is an orally active SIRT1 activator. SRTCX1003 suppresses inflammatory responses .

SRT3657	Sirtuin	Neurological Disease
SRT3657 is a brain-permeable activator of *SIRT1*, with neuroprotective effect .

Ainsliadimer C	Sirtuin	Metabolic Disease
Ainsliadimer C, a potential activator of *SIRT1*, ameliorates inflammatory responses in adipose tissue.

Inauhzin 2 Publications Verification INZ	Sirtuin MDM-2/p53	Cancer
Inauhzin is a dual *SirT1/IMPDH2* inhibitor, and acts as an activator p53, used in the research of cancer.

SRTCX1003	Sirtuin	Inflammation/Immunology
SRTCX1003 is an orally active *SIRT1* activator. SRTCX1003 suppresses inflammatory responses .

HY-124037

SRT 1460 1 Publications Verification	Sirtuin	Cancer
SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC_1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues .

HY-N9398

3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol	Sirtuin	Cancer
3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol, a *SIRT1* activator, exhibits significant stimulation of SIRT1 activity. Anti-tumor activity .

HY-N0341

Scopolin	Sirtuin	Metabolic Disease
Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots . Scopolin attenuated hepatic steatosis through activation of *SIRT1*-mediated signaling cascades .

HY-15145A

SRT 1720 dihydrochloride 30+ Cited Publications	Sirtuin Autophagy	Metabolic Disease
SRT 1720 dihydrochloride is a selective and orally active activator of *SIRT1* with an EC₅₀ of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 .

HY-15145

SRT 1720 monohydrochloride 30+ Cited Publications	Sirtuin Autophagy	Metabolic Disease
SRT 1720 monohydrochloride is a selective and orally active activator of *SIRT1* with an EC₅₀ of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 .

HY-104073

CAY10602 5+ Cited Publications	Sirtuin	Metabolic Disease Inflammation/Immunology
CAY10602 is a *SIRT1* activator. CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells .

HY-19634

YK-3-237

Sirtuin Cancer

YK-3-237, a SIRT1 activator, targets mutant p53. YK-3-237 inhibits the proliferation of triple-negative breast cancer cells .

YK-3-237	Sirtuin	Cancer
YK-3-237, a SIRT1 activator, targets mutant p53. YK-3-237 inhibits the proliferation of triple-negative breast cancer cells .

HY-E70008

Lumbokinase capsules	Sirtuin	Inflammation/Immunology
Lumbokinase capsules attenuates myocardial ischemia-reperfusion (I-R) injury through the activation of *Sirt1* signaling, and thus enhances autophagic flux and reduces I-R-induced oxidative damage, inflammation and apoptosis .

HY-117006

E1231 1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one	Sirtuin	Cardiovascular Disease
E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC₅₀=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with *SIRT1* (K_D=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE ^-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases .

HY-10532

SRT 1720 30+ Cited Publications	Sirtuin Autophagy	Metabolic Disease
SRT 1720 is a selective activator of human *SIRT1* with an EC_1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC_1.5s of 37 μM and > 300 μM, respectively.

HY-19759

SRT 2183 2 Publications Verification
SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC_1.5 value of 0.36 μM . SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels .

HY-18085G

Quercetin	PI3K Autophagy Mitophagy Apoptosis Reactive Oxygen Species	Cancer
Quercetin GMP is Quercetin (HY-18085) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Quercetin is a flavonoid antioxidant, a PI3K inhibitor and a *SIRT1* Activator .

HY-13423

Tenovin-1 3 Publications Verification	MDM-2/p53 Dihydroorotate Dehydrogenase Sirtuin Autophagy	Cancer
Tenovin-1, a p53 activator, protects p53 from MDM2-mediated degradation. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also a dihydroorotate dehydrogenase (DHODH) inhibitor .

HY-122936

Tanshindiol C	Histone Methyltransferase Keap1-Nrf2 Sirtuin	Cardiovascular Disease Cancer
Tanshindiol C is a S-adenosylmethionine-competitive EZH2 (Histone Methyltransferase) inhibitor with an IC₅₀ of 0.55 μM for inhibiting the methyltransferase activity. Tanshindiol C is also an activator of both Nrf2 and Sirtuin 1 (Sirt1) in macrophages. Tanshindiol C possesses anti-cancer activity, and can be used for atherosclerosis research .

HY-155532

10m/ZS44	Biochemical Assay Reagents	Cancer
10m/ZS44 is a blood-brain barrier-permeable Glioblastoma (GBM) inhibitor. 10m/ZS44 significantly inhibits GBM tumor growth in a mouse xenograft model. 10m/ZS44 also activates the *SIRT1/p53*-mediated apoptosis pathway, thereby inhibiting the proliferation of U251 cells .

HY-123033A

Nicotinamide riboside chloride 5+ Cited Publications	Sirtuin Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Nicotinamide riboside Chloride, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-123033

Nicotinamide riboside	Sirtuin Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Nicotinamide riboside, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-123033B

Nicotinamide riboside tartrate	Sirtuin Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Nicotinamide riboside tartrate, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-123033C

Nicotinamide riboside malate	Sirtuin Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Nicotinamide riboside malate, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-148712

SIRT6 activator 12q	Apoptosis Sirtuin	Cancer
SIRT6 activator 12q is potent, selective and orally active SIRT6 activator with IC₅₀ values of 171.20, >200, >200, >200, 0.58 μM for SIRT1, SIRT2, SIRT3, SIRT5, SIRT6, respectively. SIRT6 activator 12q inhibits cell growth and migration. SIRT6 activator 12q induces Apoptosis and cell cycle arrest at G2 phase. SIRT6 activator 12q shows anticancer activity .

HY-15510

Tenovin-6 4 Publications Verification	MDM-2/p53 Dihydroorotate Dehydrogenase Sirtuin Autophagy	Cancer
Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC₅₀s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 also inhibits dihydroorotate dehydrogenase (DHODH) .

HY-15510B

Tenovin-6 Hydrochloride 4 Publications Verification	MDM-2/p53 Dihydroorotate Dehydrogenase Sirtuin Autophagy	Cancer
Tenovin-6 Hydrochloride, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC₅₀s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH) .

HY-N3504

Ophiopogonin D'	Sirtuin	Cancer
Ophiopogonin D', isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D' shows cytotoxic activity against two human tumor cell lines MG-63 and SNU387 with IC₅₀s of 3.09 μM and 3.63 μM, respectively . Ophiopogonin D' activates *SIRT1* in a dose-dependent manner .

HY-116152

Cipepofol Ciprofol; HSK3486	GABA Receptor Sirtuin Keap1-Nrf2 Apoptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Cipepofol (Ciprofol), a novel 2,6-disubstituted phenol derivative, is a positive allosteric modulator and direct agonist of the GABA_A receptor. Cipepofol can cause the central nerve inhibition and promote sleep based on the structural modification of Propofol (HY-B0649). Cipepofol can activate the sirtuin1 (Sirt1)/Nrf2 pathway. Cipepofol protects the heart against Isoproterenol (ISO; HY-B0468)-induced myocardial infarction by reducing cardiac oxidative stress, inflammatory response and cardiomyocyte apoptosis .

HY-16558

Butein 3 Publications Verification 2’,3,4,4’-tetrahydroxy Chalcone	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a *SIRT1* activator (STAC).

HY-155784

SPC-180002	Sirtuin Reactive Oxygen Species Keap1-Nrf2	Cancer
SPC-180002 is a *SIRT1/3* dual inhibitor, with IC₅₀ values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway .

HY-148322

Sirtuin modulator 5	Sirtuin	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Sirtuin modulator 5 is a sirtuin modulating agent. Sirtuin modulator 5 can activate *SIRT1* with a DC₅₀ value of <50 μM. Sirtuin modulator 5 can be used for increasing the lifespan of a cell and used for the research of variety of diseases including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity .

HY-16561

Resveratrol Maximum Cited Publications 77 Publications Verification trans-Resveratrol; SRT501	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2	Infection Inflammation/Immunology Cancer
Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific *SIRT1* activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-N0704

Agrimol B	Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial	Infection Metabolic Disease Cancer
Agrimol B, a polyphenol, is an orally active and potent *SIRT1* activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27 .

HY-16561S1

Resveratrol-13C6 trans-Resveratrol-¹³C₆; SRT501-¹³C₆	Isotope-Labeled Compounds IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2	Infection Inflammation/Immunology Cancer
Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-16561S

Resveratrol-d4 trans-Resveratrol-d₄; SRT501-d₄	Isotope-Labeled Compounds IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2	Infection Inflammation/Immunology Cancer
Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-16561R

Resveratrol (Standard) Maximum Cited Publications 77 Publications Verification trans-Resveratrol (Standard); SRT501 (Standard)	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2	Infection Inflammation/Immunology Cancer
Resveratrol (Standard) is the analytical standard of Resveratrol. This product is intended for research and analytical applications. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific *SIRT1* activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-N10009

Cudraflavone B	NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin	Inflammation/Immunology
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of *SIRT1*. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells .

HY-W025074

BML-278	Sirtuin Histone Methyltransferase	Cancer
BML-278 is a *SIRT1* activator (EC₁₅₀: 1 μM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts .

Quercetin (GMP)	Fluorescent Dye
Quercetin GMP is Quercetin (HY-18085) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Quercetin is a flavonoid antioxidant, a PI3K inhibitor and a *SIRT1* Activator .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0341

Scopolin	Structural Classification Classification of Application Fields Anisodus tanguticus (Maxinowicz) Pascher Source classification Coumarins Metabolic Disease Arabidopsis thaliana Phenylpropanoids Plants Solanaceae Brassicaceae Disease Research Fields	Sirtuin
Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots . Scopolin attenuated hepatic steatosis through activation of *SIRT1*-mediated signaling cascades .

HY-N12386

SIRT1 activator 1	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Marine natural products Marine microorganism	Sirtuin
SIRT1 activator 1(compound 3) is a derivative of marine compound xyloallenoide A isolated from the mangrove fungus Xylaria sp.SIRT1 activator 1 shows angiogenic activities in zebrafish. SIRT1 activator 1 protects hEPC against AngII-induced senescence by increasing *SIRT1* expression levels and balancing the AMPK/Akt signaling pathway .

HY-N10083

Selaginellin	Structural Classification Source classification Phenols Polyphenols Selaginella sinensis (Desv.) Spring Selaginellaceae Plants	Reactive Oxygen Species Sirtuin
Selaginellin is an inhibitor of Reactive Oxygen Species and an activator of *SIRT1. Selaginellin protects endothelial cells against homocysteine-induced senescence by inhibitng reactive oxygen species and upregulating SIRT1* gene expression .

HY-N10125

Ainsliadimer C	Classification of Application Fields Caesalpinia crista L. Terpenoids Sesquiterpenes Source classification Metabolic Disease Plants Compositae Disease Research Fields	Sirtuin
Ainsliadimer C, a potential activator of *SIRT1*, ameliorates inflammatory responses in adipose tissue.

HY-N9398

3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol	Panax ginseng C. A. Meyer Natural Products Classification of Application Fields Source classification Plants Disease Research Fields Araliaceae Cancer	Sirtuin
3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol, a *SIRT1* activator, exhibits significant stimulation of SIRT1 activity. Anti-tumor activity .

HY-122936

Tanshindiol C	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	Histone Methyltransferase Keap1-Nrf2 Sirtuin
Tanshindiol C is a S-adenosylmethionine-competitive EZH2 (Histone Methyltransferase) inhibitor with an IC₅₀ of 0.55 μM for inhibiting the methyltransferase activity. Tanshindiol C is also an activator of both Nrf2 and Sirtuin 1 (Sirt1) in macrophages. Tanshindiol C possesses anti-cancer activity, and can be used for atherosclerosis research .

HY-123033A

Nicotinamide riboside chloride 5+ Cited Publications	Alkaloids Structural Classification Animals Neurological Disease Classification of Application Fields Anti-aging Source classification Pyridine Alkaloids Metabolic Disease Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside Chloride, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-123033

Nicotinamide riboside	Natural Products Human Gut Microbiota Metabolites Microorganisms Animals Neurological Disease Classification of Application Fields Anti-aging Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-123033B

Nicotinamide riboside tartrate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside tartrate, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-123033C

Nicotinamide riboside malate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside malate, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-N3504

Ophiopogonin D'	Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	Sirtuin
Ophiopogonin D', isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D' shows cytotoxic activity against two human tumor cell lines MG-63 and SNU387 with IC₅₀s of 3.09 μM and 3.63 μM, respectively . Ophiopogonin D' activates *SIRT1* in a dose-dependent manner .

HY-16558

Butein 3 Publications Verification 2’,3,4,4’-tetrahydroxy Chalcone	Structural Classification Chalcones Flavonoids other families Classification of Application Fields Anti-aging Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a *SIRT1* activator (STAC).

HY-16561

Resveratrol Maximum Cited Publications 77 Publications Verification trans-Resveratrol; SRT501	Structural Classification Classification of Application Fields Anti-aging Source classification Vitis vinifera cv. Zalema Plants Vitaceae Infection Microorganisms Functional Molecules Sunscreen Research of Health Products Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Cancer	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific *SIRT1* activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-N0704

Agrimol B	Agrimonia pilosa Ledeb. Structural Classification Classification of Application Fields Rosaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial
Agrimol B, a polyphenol, is an orally active and potent *SIRT1* activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27 .

HY-16561R

Resveratrol (Standard) Maximum Cited Publications 77 Publications Verification trans-Resveratrol (Standard); SRT501 (Standard)	Infection Functional Molecules Classification of Application Fields Sunscreen Anti-aging Source classification Research of Health Products Cosmetic Research Plants Inflammation/Immunology Disease Research Fields Cancer	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (Standard) is the analytical standard of Resveratrol. This product is intended for research and analytical applications. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific *SIRT1* activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-N10009

Cudraflavone B	Structural Classification Brosimopsis oblongifolia Source classification Phenols Polyphenols Plants Moraceae	NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of *SIRT1*. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells .

Cat. No.	Product Name	Chemical Structure

HY-16561S

Resveratrol-d4

Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-16561S1

Resveratrol-13C6

Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

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